Tshawb nrhiav seb yog vim li cas cov neeg siv lub cev siv Cabergoline tsis tu ncua tom qab kawm tshuaj steroids thiab muaj txiaj ntsig dab tsi thiab txaus ntshai cov tshuaj txawv txav no. Cabergoline belongs rau chav kawm ntawm cov tshuaj hu ua dopamine mimetics. Nws muaj peev xwm cuam tshuam nrog dopamine-type receptors nyob hauv lub caj pas pituitary. Qhov no ua rau muaj kev cuam tshuam tseem ceeb ntawm kev tsim cov tshuaj hormone prolactin. Hauv tshuaj, tus neeg sawv cev tau siv thaum kho tus kab mob xws li hyperprolactinemia. Cabergoline kuj tseem nquag siv hauv kev tsim lub cev.
Tsis tas li ntawd, cabergoline tuaj yeem siv tau rau kev coj khaub ncaws tsis xwm yeem, galactorrhea, kev sib deev tsawg, tsis muaj zog. Nws kuj tseem siv los tiv thaiv kev txwv ntawm txheej txheem lactation. Ntxiv rau qhov muaj peev xwm cuam tshuam nrog dopamine-type receptors, Cabergoline yog qhov tsis muaj zog agonist ntawm alpha-1 thiab alpha-2 adrenergic receptors.
Cov keeb kwm luv luv ntawm kev tsim Cabergoline
Cov tshuaj tau tsim nyob rau xyoo yim yim los ntawm Asmeskas lub tuam txhab Pharmacia. Nws tau tsim tawm hauv ntau lub tebchaws thoob ntiaj teb thiab tseem hu ua dostinex. Nws nyob hauv lub npe no tias cov tshuaj tau sau npe ua ntej thiab cov tuam txhab tsim khoom muaj cov cai patent rau nws.
Cabergoline yog ib yam tshuaj muaj ntau heev thiab tau siv nyob hauv ntau lub tebchaws thoob ntiaj teb. Dua li qhov tseeb tias txoj cai rau Dostinex cov cim lag luam tseem yog ntawm Pharmacia. Nws nyob hauv qab lub npe no nws feem ntau muag. Txawm li cas los xij, cov tshuaj muaj ntau lub npe thiab, piv txwv li, hauv Russia nws kuj tseem hu ua agalates thiab bergolac. Nws yog qhov pom tseeb tias thawj cov tshuaj muaj tus nqi ntau dua hauv kev sib piv nrog cov neeg hauv tsev.
Pharmacological teebmeem ntawm Cabergoline
Raws li peb tau hais, cabergoline yog dopamine-type receptor agonist. Cov khoom xyaw nquag ntawm cov tshuaj yog cov tshuaj dopaminergic muab los ntawm ergoline. Qhov no qhia tau tias nws muaj zog ua haujlwm qis-prolactin. Cov txheej txheem ntawm kev ua haujlwm ntawm cov tshuaj yog cuam tshuam nrog kev muaj peev xwm los ua ntawm dopamine receptors ntawm D2 hom.
Kev siv cov tshuaj hauv cov tshuaj ntau tshaj qhov kho ib leeg tuaj yeem txo qis cov tshuaj prolactin, nrog rau ua tiav cov txiaj ntsig muaj zog dopaminergic. Cov qib prolactin pib poob qis hauv peb teev los ntawm lub sijhawm siv cov tshuaj thiab tswj hwm ntawm qib uas xav tau rau ib mus rau plaub lub lis piam.
Qhov no siv rau tib neeg yam tsis muaj kab mob, nrog rau cov poj niam nrog hyperprolactomy. Tom qab yug me nyuam, cov tshuaj muaj peev xwm tswj tau qib qib ntawm prolactin rau ob rau peb lub lis piam. Muaj ntau txoj hauv kev, cov khoom txo qis hauv cov tshuaj prolactin nyob ntawm qhov ntau npaum li cas siv, uas tseem cuam tshuam rau lub sijhawm ntawm dopamine mimetic.
Nws yog ib qho tseem ceeb kom nco ntsoov tias Dostinex ua haujlwm xaiv thiab tsis muaj peev xwm cuam tshuam rau kev tsim cov tshuaj hormones sib txuas los ntawm cov qog pituitary, suav nrog cortisol. Cov tshuaj muaj, ntawm lwm yam, ntau qhov cuam tshuam uas tsis cuam tshuam nrog kev siv tshuaj kho mob. Ntawm lawv, peb nco lub peev xwm los txo cov ntshav siab. Tom qab li rau teev los ntawm lub sijhawm thov, cov nyhuv hypotensive pib tshwm rau nws tus kheej, thiab nws lub zog nyob ncaj qha rau ntawm cov tshuaj siv.
Cabergoline hauv kev tsim lub cev: cov khoom zoo
Cov tshuaj yog xaiv agonist ntawm dopamine-hom receptors thiab tib lub sijhawm ua haujlwm tshwj xeeb. Nws yuav tsum tau sau tseg nws qhov zoo sib xws nrog D2 receptors, tab sis cov tshuaj cuam tshuam tsis zoo nrog adrenergic (alpha-1 thiab alpha-2) thiab serotonin (5-HT1, 5-HT2) receptors.
Rau kev kho mob lub hom phiaj, tus neeg sawv cev no tau siv los kho tus mob hyperprolactinemia, kev ua haujlwm tsis txaus ntawm cov tshuaj hormone prolactin los ntawm lub caj pas pituitary, nrog rau Parkinson tus kab mob. Cov tshuaj muaj peev xwm siab los tiv thaiv cov tshuaj prolactin thiab nws yog vim li no cov cabergoline thiaj nrov heev hauv kev tsim kho lub cev. Tib lub sijhawm, tus neeg sawv cev cuam tshuam nrog D2 receptors. Yog li, dopamine dhau los ua qhov tsis zoo rau kev tso tawm prolactin.
Peb twb tau hais tias qhov tseem ceeb ntawm cov tshuaj yog nws tsis muaj peev xwm cuam tshuam cov txheej txheem ntawm kev sib xyaw ntawm lwm cov tshuaj hormones tsim tawm los ntawm cov txheej txheem cellular ntawm cov qog pituitary - corticotropin, kev loj hlob hormone, luteinizing, thiab cov thyroid stimulating hormones.
Prolactin yog ib tus tswv cuab ntawm tib pab pawg ntawm cov tshuaj hormones raws li kev loj hlob hormone. Nws yog ib yam tshuaj peptide, cov qauv uas muaj 199 amines. Txawm hais tias nws qhov loj me me siab dua li ntawm kev loj hlob hormone, prolactin muaj ntau txoj hauv kev zoo ib yam li kev loj hlob hormone. Txawm li cas los xij, thaum kev sib tham tig mus rau cov qauv ntawm cov tshuaj no, txhua qhov zoo sib xws tam sim ntawd ploj mus.
Prolactin tsis muaj peev xwm nthuav tawm cov khoom siv anabolic, tab sis yog npaj los txhawb cov txheej txheem lactation. Qhov tseeb no qhia tias dostinex tseem ceeb heev rau cov poj niam vim nws lub cev muaj zog. Qhov no yog qhov pom tau ntau tshaj thaum cev xeeb tub, vim tias nws tso cai rau koj kom nrawm cov txheej txheem ntawm kev tsim cov kua mis. Cov tshuaj kuj tseem tuaj yeem siv nyob rau lub sijhawm tom qab yug me nyuam nrog cov tshuaj hypersynthesis mis los txhawm rau txhawm rau cov txheej txheem no.
Tam sim no, cov kws tshawb fawb tsis paub tus nqi kho mob ntawm prolactin cuam tshuam nrog txiv neej lub cev. Nws tau tsim los tias qhov siab ntawm cov tshuaj hormones no tuaj yeem ua rau kev txhim kho kev tsis muaj zog, tsis muaj menyuam thiab gynecomastia. Txawm li cas los xij, kev tsis sib haum xeeb ntawm cov kws tshawb fawb txog qhov khoom kawg ntawm prolactin tsis tso tseg thiab tsis yog txhua tus ntawm lawv ntseeg tias qhov no tuaj yeem ua tau.
Gynecomastia tsis tshua muaj tshwm sim hauv cov txiv neej zoo tib yam, tab sis tsis txawv hauv AAS cov neeg siv. Qhov no yog ib qho laj thawj cabergoline thiaj nrov nyob hauv kev tsim lub cev. Nco tseg tias lactation gynecomastia nrog rau kev tso me me ntawm cov kua thaum lub txiv mis raug zawm. Cov kab mob no muaj peev xwm ua kom nce ntxiv, thiab qhov tseeb no tau paub rau ntau tus neeg ncaws pob. Thaum xub thawj cov cim ntawm kev txhim kho gynecomastia, lawv tau hloov kho kom haum rau lawv chav kawm ntawm anabolic steroids.
Lactational gynecomastia tsis nkag siab thiab yog vim li cas rau nws txoj kev txhim kho tau suav tias yog qhov tsis sib xws ntawm prolactin, estrogens thiab androgens. Tsis tas li, tus kab mob tuaj yeem tshwm sim los ntawm kev tshuaj ntsuam genetic predisposition. Txhawm rau zam txhua qhov teeb meem no, nws yuav tsum siv cabergoline hauv kev tsim lub cev.
Yog tias koj txheeb xyuas qhov profile cov peev txheej hauv web, tom qab ntawd cov kis las tsis tshua nco qab qhov nce siab ntawm prolactin. Tib lub sijhawm, qhov xav tau siv dostinex nyob ntawm qhov no. Nws tau tsim los tias cov tshuaj estrogens txhawb kev loj hlob ntawm qib prolactin thiab qhov no yog qhov laj thawj tseem ceeb rau kev txhim kho lactation gynecomastia.
Tab sis muaj cov txiaj ntsig tshawb fawb uas hais lus zoo txog kev muaj peev xwm txwv tsis pub muaj qee yam tshuaj tiv thaiv prolactin, piv txwv li, androgens. Qhov no muab rau peb qhov laj thawj hais tias tsis yog tsuas yog nce qib tshuaj estrogen yog qhov laj thawj tseem ceeb rau kev txhim kho ntawm lactation gynecomastia.
Txog rau hnub tim, ob peb txoj kev tshawb fawb tau ua tiav hauv cov lus qhia no. Qhov tseeb, tsis muaj ib yam yuav xav tsis thoob, vim tias tus kab mob no yuav luag ib txwm pom tsuas yog hauv cov kis las uas nquag siv tshuaj steroids. Hauv cov txiv neej zoo tib yam, tus kab mob no tsis tshua pom muaj.
Txawm li cas los xij, peb pom cov txiaj ntsig ntawm ib qho kev sim uas tshawb xyuas qhov ua tau zoo ntawm ob testosterone esters (propionate thiab enanthate) ntawm cov tshuaj prolactin. Qhov nce tseem ceeb hauv kev mloog zoo ntawm cov tshuaj poj niam no tau pom nyob rau hnub plaub ntawm chav kawm. Hauv qhov kev sim zaum thib ob, kev nce qib ntawm qib ntawm cov tshuaj hormone tau teev tseg tom qab siv AAS. Vim li ntawd, qib ntawm prolactin tau mus txog yuav luag cov qib uas yog tus yam ntxwv ntawm poj niam lub cev.
Yuav siv Cabergoline li cas rau lub cev?
Hauv kev kho mob, tshuaj tau siv los ntawm cov txiv neej txhawm rau txhawm rau tsim cov tshuaj prolactin ntau npaum li 0.5 grams hauv ib lub lis piam. Cov tshuaj tuaj yeem siv tau ib zaug lossis faib ua ob lossis ntau zaug. Koj tseem tuaj yeem nce qhov kev siv Dostinex kom tau txais txiaj ntsig zoo dua los ntawm kev siv 0.5 grams txhua txhua peb lossis plaub hnub.
Cabergoline hauv kev tsim lub cev yog siv thaum kawm AAS, uas suav nrog cov tshuaj steroids nrog cov haujlwm progestogenic (trenbolones, oxymetholone lossis trenbolone). Qhov koob tshuaj yog 0.25 grams txhua hnub thib peb. Lub sijhawm kawm Dostinex yog ib hlis, tom qab uas nws tau siv raws li xav tau.
Muaj qee kis thaum cov tshuaj tau siv los ntawm cov txiv neej kom ua tiav ntau qhov kev sib deev thaum sib deev. Qhov tseeb no tuaj yeem piav qhia los ntawm tus nqi siab ntawm dopamine synthesis thaum sib deev. Tom qab lub cev, tso tawm qhov muaj zog ntawm prolactin tau pom thiab txhua qhov kev sau dopamine tau nruab nrab. Qhov tseeb no muaj feem cuam tshuam nrog qhov tseeb tias tom qab lub cev, kev sib deev arousal ntawm cov txiv neej sai sai. Yog tias koj thaiv cov tshuaj prolactin nrog Dostinex, tom qab ntawd ntau qhov kev sib deev tau dhau los ua qhov tseeb. Cov kis las ncaws pob tsis siv cabergoline.
Dab tsi tshwm sim tshwm sim thaum siv Cabergoline?
Hauv kev ua kis las, cov tshuaj raug txiav txim siab muaj kev nyab xeeb, txawm hais tias qee cov kev mob tshwm sim muaj nyob hauv nws. Mob taub hau (26 feem pua), xeev siab (27 feem pua), thiab ntuav feem ntau tshwm sim hauv kev tshawb fawb. Cov txiaj ntsig tsis zoo tom kawg tau sau tseg tsuas yog ob feem pua ntawm cov ncauj lus.
Nws tseem yuav tsum tau sau tseg tias lwm cov kev mob tshwm sim tuaj yeem ua tau, tab sis lawv qhov kev tshwm sim tsis tshua muaj neeg pom. Txhua qhov tsis zoo ntawm Dostinex cuam tshuam ncaj qha rau cov tshuaj siv. Qhov no qhia tias koj yuav tsum pib noj tshuaj nrog qhov tsawg kawg nkaus thiab, yog tias tsim nyog, nce nws.
Kev qhia thiab contraindications rau kev siv Cabergoline
Yog tias peb tham txog kev ncaws pob, cov tshuaj feem ntau yog siv txhawm rau txhawm rau txhawm rau ua haujlwm progestogenic ntawm ntau AAS. Hauv tshuaj, tshuaj tau qhia rau poj niam siv los kho qee yam kab mob. Txawm hais tias cov tshuaj tau txiav txim siab tias muaj kev nyab xeeb, vim tias thaum nws tau siv hauv cov tshuaj pom zoo, kev pheej hmoo ntawm kev phiv tshuaj yog me me, muaj qee qhov contraindications rau nws siv. Peb tab tom tham txog cov tib neeg hnub nyoog qis dua 16 xyoo, kev nkag siab ntawm lub cev mus rau txhua yam khoom hauv cov tshuaj. Koj yuav tsum tau ceev faj hauv nws siv thaum muaj qee yam mob.
Xav paub ntau ntxiv txog Cabergoline thiab nws siv hauv cov vis dis aus hauv qab no:
