Tshawb nrhiav seb cov qib nitrogen ntau npaum li cas tuaj yeem ua rau muaj zog thiab nce cov leeg nqaij hauv kev tsim lub cev. Pib qoj ib ce tam sim no. Nitric oxide yog pawg nitrogen uas txuas nrog cov pa oxygen molecule. Nrog cov qauv yooj yim heev ntawm cov molecule, cov khoom no zoo li yog qhov nthuav heev, vim nws ua haujlwm ntau hauv lub cev. Hnub no peb yuav tham txog qhov sib txawv mus kom nce qib nitric oxide.
Dab tsi yog nitric oxide?
Tau ntau xyoo, nitric oxide tau suav hais tias yog cov khoom siv tsis yooj yim, vim nws yog cov pa roj av uas nyob hauv peb vib nas this tom qab kev sib xyaw. Cov kws tshawb fawb tsuas paub tseeb tias cov khoom sib xyaw ua ke hauv cov hlab ntshav, uas ua rau muaj kev so sai ntawm cov leeg ntawm cov hlab ntsha. Raws li qhov tshwm sim, qhov no ua rau txo qis hauv cov ntshav thiab ua rau kom cov ntshav khiav nrawm dua.
Tsuas yog xyoo 1998, cov kws tshawb fawb muaj peev xwm cais cov nitric oxide thiab rau qhov no lawv tau txais khoom plig Nobel. Lawv kuj tau tswj hwm los qhia qhov cuam tshuam uas nitric oxide muaj rau cov hlab plawv. Tab sis tsis tsuas yog qhov no nthuav rau NO, tab sis kuj muaj coob tus ntawm lwm cov haujlwm. Piv txwv li, nitric oxide pab tsim kev sib txuas tshiab ntawm cov cell hauv lub paj hlwb hauv lub hlwb. Niaj hnub no, cov kws tshawb fawb paub tias nyob rau theem qis ntawm NO, cov khoom muaj txiaj ntsig zoo rau lub cev, tab sis nyob rau qhov siab nws tuaj yeem dhau los ua cov tshuaj lom muaj zog.
Ua ntej tshaj plaws, qhov tseeb no tau piav qhia los ntawm qhov tseeb tias nitric oxide yog dawb radical, uas, nyob rau qee qhov xwm txheej, hloov mus rau peroxynitrite. Cov tshuaj no ua rau muaj kev phom sij loj rau cov txheej txheem cellular ntawm txhua daim ntaub ntawm lub cev. Yog tias ib tus neeg txhim kho ntshav lom (sepsis), tom qab ntawd lub zog ntawm septic shock yog cuam tshuam nrog qib nitric oxide.
Tsis ntev los no, cov kws tshawb fawb tau tshawb pom qhov laj thawj yog vim li cas, ua tsaug rau kev txhawb zog, koj tuaj yeem zam kev mob plawv. Qhov no yog vim qhov tseeb tias nyob rau hauv kev cuam tshuam ntawm kev ntxhov siab, kev tsim cov nitric oxide tau nrawm dua, uas tau khaws cia hauv lub plawv thiab ntshav hauv daim ntawv ntawm ob yam tshuaj - nitrosothiol thiab nitrate. Yog tias tsim nyog, cov ua ntej no tuaj yeem hloov pauv sai sai rau NO. Qhov no yog qhov ua rau muaj kev nce nrawm ntawm cov ntshav ntws thiab, vim li ntawd, txhim kho cov pa oxygen rau lub plawv. Kev cob qhia lub zog kuj tseem pab txhawb kev ua kom nrawm ntawm cov synthetase tseem ceeb, uas yog lub luag haujlwm rau kev tsim cov nitric oxide.
Yuav ua li cas kom nce qib nitric oxide?
Muaj ntau ntau cov tshuaj ntxiv ntawm kev ua lag luam khoom noj khoom haus niaj hnub no uas yuav tsum nce siab ntawm nitric oxide. Qhov no feem ntau yog vim qhov tseeb tias nitric oxide muaj peev xwm ua kom cov ntshav ntws nrawm dua thiab, vim li ntawd, nce cov leeg nqaij. Rau qhov laj thawj pom tseeb, qhov no ua rau nce ntxiv hauv kev siv thiab ua haujlwm tau zoo ntawm kev qhia.
Nws kuj tseem yuav tsum tau nco txog qhov muaj peev xwm ntawm NO txhawm rau nce tus nqi ntawm kev sib xyaw ntawm cov tshuaj hormones anabolic, uas ua kom nrawm dua cov txheej txheem rov ua haujlwm. Feem coob ntawm cov tshuaj muaj arginine, uas yog lub hauv paus tseem ceeb ntawm nitric oxide hauv lub cev.
Peb twb tau hais tias ntawm qee qhov concentration ntawm nitric oxide, cov ntshav ntws nce nrawm dua thiab, vim li ntawd, cov leeg ua haujlwm thiab ua kom cov nqaij mos noj tau zoo. Tab sis tib lub sijhawm, nitric oxide kuj tseem txhawb kev ua kom nrawm ntawm kev sib xyaw ntawm kev loj hlob hormone, uas txhais tau tias nws siv sijhawm tsawg dua rau lub cev kom rov zoo. Nws kuj tseem yuav tsum tau ceeb toom txog kev muaj peev xwm ntawm nitric oxide txhawm rau qhib kev loj hlob ntawm lub xov tooj cua satellite, vim tias cov txheej txheem ntawm kev rov ua haujlwm thiab kev loj hlob tau tshwm sim. Cov amino acid compound arginine feem ntau pom muaj nyob hauv feem ntau NO-txhawb cov tshuaj ntxiv. Cov khoom no yog pub dawb ntawm nitric oxide thiab tau paub rau ntau tus. Txawm li cas los xij, lub hauv paus tseem ceeb uas txwv qhov tsim tawm NO yog tsis txhais tau tias yog arginine, tab sis tshwj xeeb cov enzymes nyob hauv cov ntaub so ntswg endothelial. Yog tias ib tus neeg muaj kev puas tsuaj rau cov ntaub so ntswg endothelial, uas tuaj yeem tshwm sim, piv txwv li, los ntawm ntshav siab, tom qab ntawd kev ua haujlwm ntawm cov enzymes uas sib xyaw nitric oxide tsis zoo. Lawv cov tshuaj ntxiv nrog arginine tuaj yeem ua kom tsis muaj ntau lawm.
Tab sis txawm hais tias tus kis las tsis muaj kev puas tsuaj rau cov ntaub so ntswg endothelial, tom qab ntawd qhov teeb meem thib ob kuj tseem tuaj yeem ua tau, txwv tus nqi ntawm nitric oxide ntau lawm. Peb tam sim no tham txog enzyme arginase. Cov tshuaj no koom nrog hauv kev tawg ntawm arginine. Qhov siab dua amine concentration, cov nquag ua arginase yog.
Hauv ib txoj kev tshawb nrhiav, 20 txog 30 grams ntawm arginine tau txhaj tshuaj rau hauv cov hlab ntshav kom nrawm nitric oxide synthesis. Cov txiaj ntsig tau zoo heev. Txawm li cas los xij, nrog rau qhov ncauj ntawm arginine, qhov kev ua tiav no tsis tuaj yeem rov ua dua. Qhov no yog vim qhov tseeb tias thaum ntau dua 10 grams ntawm cov ntsiav tshuaj arginine tau noj, lub plab zom mov cuam tshuam. Txawm li cas los xij, qhov siab ntawm NO yog siab dhau thiab tsis xav tau, vim cov khoom no tuaj yeem dhau los ua cov tshuaj lom.
Koj yuav tsum nco ntsoov tias nitric oxide tau muab coj los ua ke nyob rau hauv kev ua haujlwm ntawm lub cev, thiab ntau dua koj qhov kev paub dhau los, ntau TSIS tau tsim tawm hauv lub cev. Nov yog ib qho laj thawj rau kev txhim kho kev ua haujlwm ntawm lub plawv thiab cov hlab ntshav nyob rau hauv kev cuam tshuam ntawm kev siv lub cev. Peb twb tau hais tias nitric oxide yog roj uas decomposes sai tom qab tsim khoom. Vim li no, txhawm rau txiav txim siab qhov concentration ntawm cov tshuaj, nws yog qhov yuav tsum tau kawm nws cov metabolites.
Arginine tsis yog tib qho uas ua rau nce qib ntawm nitric oxide ntau lawm. Piv txwv li, qej muaj cov pab pawg sulfuric ua ntej NO, thiab cov txiv kab ntxwv muaj cyrulin, uas tuaj yeem hloov pauv mus rau hauv arginine, thiab tom qab ntawd nkag mus rau nitric oxide. Vim tias muaj cov polyphenols nyob hauv cocoa, uas tiv thaiv kev puas tsuaj ntawm nitric oxide, cov khoom no tseem ua rau nrawm ntawm kev sib xyaw ntawm NO.
Tsis ntev los no, cov kws tshawb fawb tau tshawb xyuas cov tshuaj ntxiv uas muaj pyrites (pom hauv beets) thiab cov enzyme tshwj xeeb (pom hauv hawthorn) uas ua kom nrawm hloov pauv ntawm pyrites rau hauv nitrates thiab tom qab ntawd mus rau nitric oxide. Cov tshuaj ntxiv no tsis yog tsuas yog nce siab ntawm nitric oxide, tab sis cov tshuaj suav nrog hauv nws cov muaj pes tsawg leeg tuaj yeem hla dhau cov teeb meem arginine. Vitamin C kuj tseem muaj qhov cuam tshuam zoo rau tus nqi ntawm NO ntau lawm. Tam sim no cov kws tshawb fawb tab tom nrhiav lwm yam tshuaj uas yuav muaj txiaj ntsig zoo dua hauv kev tsim cov tshuaj nitric oxide piv rau cov arginine tam sim no.
Yog xav paub ntxiv txog nitrogen tshuav nyiaj li cas, saib daim vis dis aus no:
