Tshawb nrhiav seb cov kis las ncaws pob zoo li cas hauv ntau yam kis las cuam tshuam nrog qhov mob thiab siv tshuaj dab tsi. Nimesulide (Nise) koom nrog cov tshuaj tsis-steroidal anti-inflammatory tshuaj thiab, tsis zoo li feem ntau analogues, muaj peev xwm xaiv tau txwv tsis pub siv isoform tshwj xeeb ntawm cyclooxygenase CTC-2. Txawm li cas los xij, nws tsis cuam tshuam rau lub cev lub cev ntawm cov tshuaj no - COX -1. Cov tshuaj no yog thawj tus xaiv COX-2 inhibitor tsim los ntawm cov kws tshawb fawb.
Txij li feem ntau ntawm cov sib piv ntawm cov tshuaj ib txhij txwv ob qho isoforms ntawm cyclooxygenase, qhov ntau ntawm lawv siv tau txo qis, vim tias lawv muaj qhov tsis zoo ntawm lub plab zom mov thiab tuaj yeem ua rau muaj ntau qhov tshwm sim. Tsis tas li, ntawm qhov zoo ntawm kev siv Nise lossis Nimesulide hauv kev ncaws pob thiab tsim lub cev, nws yog qhov tsim nyog los hais txog qhov tsis muaj acidic ntawm cov tshuaj. Vim li ntawd, nws tau zoo dua los ntawm lub cev hauv kev sib piv nrog analogues.
Vim nws lub peev xwm tsis cuam tshuam rau COX-2, Nimesulide tsis tshua ua rau kev txhim kho ntawm cov kev mob tshwm sim hauv lub plab zom mov. Lwm qhov tseem ceeb ntawm kev nyab xeeb siab ntawm cov tshuaj yog nws cov tshuaj antihistamine thiab antibradykinin cov khoom. Nise tau tsim los ntawm Indian tuam txhab kws kho mob Dr. Reddy's Laboratories Ltd thiab yog rau cov tshuaj tsis-steroidal anti-inflammatory tshuaj ntawm pab pawg sulfonamide. Nimesulide, nyeg, yog lub npe tsis muaj npe thoob ntiaj teb thiab zoo ib yam li Nise.
Nise lossis Nimesulide hauv kev ncaws pob thiab tsim lub cev: cov txheej txheem ntawm kev ua haujlwm
Txhawm rau nkag siab zoo yuav siv Nise lossis Nimesulide li cas hauv kev ncaws pob thiab tsim lub cev, koj yuav tsum nkag siab cov txheej txheem ntawm cov tshuaj. Nws muaj peev xwm ua kom muaj zog tiv thaiv kev tiv thaiv kab mob thromboxane xws li B2 hauv lub ntsws cov nqaij. Ntawm qhov zoo ntawm tus neeg sawv cev no, nws yuav tsum tau sau tseg tias muaj peev xwm los txwv tsis pub tso cov tshuaj histamine. Qhov no qhia tias cov tshuaj tuaj yeem siv tau los ntawm cov neeg mob hawb pob.
Cov tshuaj, zoo li nws cov metabolites, muaj cov tshuaj tiv thaiv kab mob thiab ua tau zoo hauv kev cuam tshuam nrog ntau hom dawb radicals. Ib nrab ntawm lub neej ntawm cov tshuaj tiv thaiv nquag nyob hauv thaj tsam ntawm 1.8-4.7 teev, tab sis tib lub sijhawm nws tuaj yeem txwv TsOP-2 tsawg kawg yim teev. Thiab yog tias kev sib tham los txog qhov cuam tshuam ntawm cov tshuaj no hauv cov kua dej synovial, tom qab no lub sijhawm ua haujlwm ntawm Nimesulide tseem ntev dua thiab yog li 12 teev nrog rau kev noj tshuaj txhua hnub ntawm 0.2 grams, siv rau ib lub lim tiam.
Tam sim no cov kws kho mob tau them nyiaj ntau rau qhov cuam tshuam ntawm cov tshuaj tsis-steroidal anti-inflammatory rau ntawm cov nqaij mos ntawm cov cuab yeej sib txuas-ligamentous. Tus neeg sawv cev tuaj yeem ua rau qeeb cov txheej txheem ntawm degranulation ntawm proteoglycans, ntxiv rau kev tsim cov stromelysin. Nyob rau tib lub sijhawm, kev sib txuas ntawm collagenase hlau-proteinase tau txo qis. Hais txog kev ua kom loog, Nise ze rau indomethacin, piroxicam thiab diclofenac. Thaum siv cov tshuaj hauv qhov nyiaj ntawm 0.2 grams thoob plaws ib hnub, nws cov nyhuv antiperetic zoo ib yam li paracetamol ntawm qhov ntau npaum li 0.5 grams. Ntxiv mus, qhov no muaj tseeb tsis yog rau cov neeg laus nkaus xwb, tab sis kuj rau menyuam yaus.
Kev qhia thiab contraindications rau kev siv Nise lossis Nimesulide hauv kev ncaws pob thiab tsim lub cev
Cia peb paub seb qhov twg siv Nise lossis Nimesulide hauv kev ncaws pob thiab tsim lub cev tsim nyog:
- articular syndrome thaum lub sij hawm exacerbation ntawm gout;
- rheumatoid thiab mob caj dab psoriatic;
- osteochondrosis;
- myalgia ntawm tsis-rheumatic thiab rheumatic genesis.
Cov tshuaj no feem ntau yog npaj rau kev kho tus mob, txo qhov mob thiab daws qhov mob. Txawm li cas los xij, nws yuav tsum nco ntsoov tias Nimesulide tsuas yog siv tau thaum siv thiab tsis tuaj yeem cuam tshuam qhov kev loj hlob ntawm tus kab mob.
Ntawm qhov contraindications rau kev siv tshuaj, peb nco lub sijhawm ua rau mob hnyav thiab mob hnyav ntawm lub plab zom mov, qhia tau hais tias lub siab lossis lub raum tsis ua haujlwm, nrog rau qhov ua rau bronchial spasm thaum siv acetylsalicylic acid lossis lwm yam tsis-steroidal anti -tshuaj tua kab mob. Thiab, tau kawg, lub sijhawm cev xeeb tub thiab lactation, uas yog qhov nkag siab heev.
Peb kuj tseem nco ntsoov tias qee zaum nws yog qhov tsim nyog yuav tsum tau siv Nise nrog kev ceev faj. Qhov no siv rau lub plawv tsis ua hauj lwm, hom 2 mob ntshav qab zib, teeb meem ntawm cov txheej txheem coagulation, ntshav siab, nrog rau thaum laus. Ib qho ntxiv, cov tshuaj yuav tsum tsis txhob siv los ntawm menyuam yaus hnub nyoog qis dua 12 xyoos, thiab thaum muaj lub raum tsis ua haujlwm ntev, yuav tsum tau txo qis txhua hnub rau 0.1 grams.
Yuav siv Nise lossis Nimesulide li cas hauv kev ncaws pob thiab tsim lub cev kom raug?
Cov kws kho mob pom zoo kom siv Nise lossis Nimesulide hauv kev ncaws pob thiab tsim lub cev hauv qhov tsawg kawg nkaus kom tau txais txiaj ntsig zoo hauv cov chav kawm luv. Cov ntsiav tshuaj yuav tsum tau noj tom qab noj mov thiab ntxuav nrog dej kom ntau. Cov nyhuv analgesic ntawm cov tshuaj yuav tshwm sim li ntawm peb lub hlis twg ntawm ib teev tom qab noj nws. Nws raug nquahu kom noj ib ntsiav tshuaj ob zaug ib hnub. Yog tias muaj teeb meem nrog kev ua haujlwm ntawm lub plab zom mov, tom qab ntawd nco ntsoov noj Nise thaum noj mov tas lossis tom qab nws. Nco ntsoov tias qhov siab tshaj plaws txhua hnub ntawm cov tshuaj yog 0.2 grams.
Ntawm cov neeg uas muaj teeb meem nrog kev ua haujlwm ntawm cov leeg musculoskeletal, kwv yees li ib feem peb muaj cov hlab ntshav siab. Nws tau tsim tau zoo tias txhua yam tshuaj tsis-steroidal anti-inflammatory ua rau nce ntshav siab. Nyob rau tib lub sijhawm, Nimesulide yog xaiv cov tshuaj COX-2 thiab tsis muaj qhov cuam tshuam zoo li no. Peb kuj nco ntsoov tias qhov tshuaj no tsis cuam tshuam rau kev ua haujlwm tau zoo ntawm cov tshuaj tsim los txo cov ntshav siab.
Cov kab mob tshwm sim feem ntau ntawm cov leeg musculoskeletal yog osteoarthritis deformans thiab, ua ntej tshaj plaws, nws txhawj xeeb txog cov neeg muaj hnub nyoog 65 xyoos. Cov kab mob sib kis feem ntau tshwm sim, tig mus, yog mob caj dab rheumatoid, thiab yog tias kuaj pom ntau dua peb txog tsib xyoos, kev xiam oob qhab tuaj yeem tshwm sim.
Hauv kev tshawb fawb tshuaj, nws tau pom tias Nimesulide tsis muaj lub zog cardiotoxicity hauv kev sib piv nrog analogues. Qhov no ua rau nws muaj peev xwm siv nws los ntawm cov neeg muaj kev pheej hmoo ntawm kev mob plawv. Hauv ib txoj kev tshawb fawb hauv cov neeg uas tau phais rau mob plawv ischemic, tsis muaj kev phiv tshuaj pom. Nco ntsoov tias thaum lub sijhawm sim, cov ncauj lus tau siv Nise ob zaug ib hnub ntawm ib koob ntawm 0.1 grams.
Muaj cov ntaub ntawv pov thawj tshawb fawb pom tias Nimesulide muaj txiaj ntsig zoo rau kev mob prostatitis thaum cov neeg mob tau hnov mob hauv thaj tsam plab. Lawv noj 0.1 grams tshuaj ob zaug ib hnub rau 20 hnub. Nco ntsoov tias Nise tau qhia nws tus kheej ntawm qhov zoo hauv chav kawm ntawm kev tshawb fawb ntau.
Nimesil, Nise lossis Nimesulide hauv kev ncaws pob thiab tsim lub cev: uas zoo dua?
Heev feem ntau, cov kis las tau ntsib nrog cov lus nug uas ntawm peb yam tshuaj twg zoo dua. Nws yuav tsum tau hais tam sim ntawd Nimesil yog cov tshuaj qub, thiab ob qho ntxiv yog cov generics, uas tau txiav txim siab ua ntej lawv tus nqi qis. Tag nrho cov tshuaj no siv ib yam khoom los ua cov khoom xyaw nquag. Qhov sib txawv ntawm qhov muaj pes tsawg leeg yog tshwm sim los ntawm cov khoom siv ntxiv uas tsis cuam tshuam loj rau kev ua haujlwm ntawm cov tshuaj.
Txhua yam ntawm cov khoom no muaj qhov qhia zoo ib yam rau kev siv, thiab tseem tuaj yeem ua rau muaj kev phiv zoo sib xws. Peb twb tau hais tias hais txog qhov tsis zoo, Nise yog ib yam tshuaj muaj kev nyab xeeb. Txawm hais tias lub hom phiaj tseem ceeb ntawm kev siv tshuaj Nimesulide ua cov khoom muaj txiaj ntsig yog txhawm rau daws qhov mob thiab kho kab mob ntawm cov leeg nqaij pob txha, lawv kuj tuaj yeem siv los daws lwm yam teeb meem.
Ntawm qhov sib txawv ntawm Nise thiab analogues yog qhov muaj qhov zoo li daim ntawv tso tawm raws li kev ncua. Raws li qhov tshwm sim, cov tshuaj tuaj yeem siv los ntawm menyuam yaus hnub nyoog ob xyoos. Ib qho ntxiv, muaj cov ntsiav tshuaj yaj uas tau tso cai siv txij hnub nyoog peb xyoos. Nimesil tsis siv rau hauv kev kho menyuam yaus.
Raws li peb tau hais, txhua yam tshuaj tuaj yeem ua rau muaj kev phiv zoo sib xws, uas, txawm li cas los xij, yog qhov tsawg heev. Nws yog ib qho tseem ceeb heev uas yuav tsum ua raws txoj cai rau kev siv cov tshuaj no. Txawm li cas los xij, nqe lus no muaj tseeb rau txhua yam tshuaj, vim tias txhua tus ntawm nws muaj nws qhov tsis zoo.
Yog tias Nimesil tsis tuaj yeem siv los ntawm menyuam yaus thiab cov neeg muaj ntshav qab zib hom 2, ces Nimesulide muaj kev ywj pheej dua hauv qhov no. Txawm li cas los xij, hauv cov xwm txheej zoo li no, nws yog qhov yuav tsum tau ua tib zoo saib xyuas thiab tsis txhob siv cov tshuaj loj. Txawm hais tias qee tus kws kho mob paub tseeb tias kev ua haujlwm tsis zoo thiab ua rau muaj kev phom sij ntau dua rau lub cev, tsis muaj pov thawj tshawb fawb txog qhov no. Niaj hnub no hauv cov khw muag tshuaj koj tuaj yeem pom muaj ntau tus lej, thiab lawv tau nquag siv, vim tias lawv cov nqi tsawg dua li ntawm cov tshuaj qub. Txawm li cas los xij, peb pom zoo kom koj sab laj nrog koj tus kws kho mob ua ntej siv cov tshuaj.
Yog xav paub ntxiv txog kev siv tshuaj tsis-steroidal anti-inflammatory tshuaj hauv kev ncaws pob:
